Gene Therapy

Reports summarize gene therapy research from Case Western Reserve University, Department of Biochemistry

Published in Gene Therapy Weekly, May 1st, 2008

New research, 'Doublesex and the regulation of sexual dimorphism in Drosophila melanogaster: STRUCTURE, FUNCTION, AND MUTAGENESIS OF A FEMALE-SPECIFIC DOMAIN,' is the subject of a report. According to a study from the United States, "The DSX (Doublesex) transcription factor regulates somatic sexual differentiation in Drosophila. Female and male isoforms (DSX F and DSX M) are formed due to sex-specific RNA splicing."

"DNA recognition, mediated by a shared N-terminal zinc module (the DM domain), is enhanced by a C-terminal dimerization element. Sex-specific extension of this element in DSX F and DSX M leads to assembly of distinct transcriptional preinitiation complexes....

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Source: Gene Therapy Weekly (2008-05-01)

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