Gene Therapy

Skaggs Institute for Chemical Biology reports research in gene therapy

Published in Gene Therapy Weekly, May 1st, 2008

Scientists discuss in 'Modulation of drug resistance by artificial transcription factors' new findings in gene. "The efficiency of chemotherapeutic treatments in cancer patients is often impaired by the acquisition of drug resistance. Cancer cells develop drug resistance through dysregulation of one or more genes or cellular pathways," investigators in the United States report.

"To isolate efficient regulators of drug resistance in tumor cells, we have adopted a genome-wide scanning approach based on the screening of large libraries of artificial transcription factors (ATFs) made of three and six randomly assembled zinc finger domains. Zinc finger libraries were linked...

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Source: Gene Therapy Weekly (2008-05-01)

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