Cancer Gene Therapy

Studies from M.C. Bajgelman et al add new findings in the area of cancer gene therapy

Published in Gene Therapy Weekly, May 1st, 2008

"Here we introduce a new adenoviral vector where transgene expression is driven by p53. We first developed a synthetic promoter, referred to as PGTx beta containing a p53-responsive element, a minimal promoter and the first intron of the rabbit P-globin gene," investigators in Sao Paulo, Brazil report.

"Initial assays using plasmid-based vectors indicated that expression was tightly controlled by p53 and was 5-fold stronger than the constitutive CMV immediate early promoter/enhancer. The adenoviral vector, AdPG, was also shown to offer p53-responsive expression in prostate carcinoma cells LNCaP (wt p53), DU-145 (temperature sensitive mutant of p53) and PC3 (p53-null,...

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Source: Gene Therapy Weekly (2008-05-01)

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