Apoptosis

New apoptosis research from Seoul National University, Medical Department discussed

Published in Gene Therapy Weekly, May 1st, 2008

According to a study from Seoul, South Korea, "Secreted frizzled-related proteins (sFRPs) are modulators of Wnt signaling. This study was undertaken for definitive assessment of contribution of different sFRPs in osteoblastic differentiation of mesenchymal progenitor cells and apoptosis of osteoblasts."

"Treatment of C3H10T1/2 cells with sFRP-2 at concentrations of 10, 50, and 100 nM and sFRP-4 at low concentrations (5 nM) significantly increased Wnt-3A-induced alkaline phosphatase (ALP) activities, whereas sFRP-1 or 3 did not. Retroviral transduction of the sFRP2 but not other sFRPs also significantly enhanced ALP activity induced by P-glycerophosphate and ascorbic...

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Source: Gene Therapy Weekly (2008-05-01)

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