Gene Therapy

Research conducted at University of Leuven, Gene Therapy Center has provided new information about gene therapy

Published in Gene Therapy Weekly, May 1st, 2008

"Acute renal failure (ARF) is a major worldwide cause of morbidity and mortality, lacking specific targeted, effective therapies. Renal tubular cell apoptosis has been recognized to play a critical role in the pathogenesis of ARF, yet few studies have evaluated whether intervention in apoptotic pathways can ameliorate the deterioration in renal function associated with ARF," researchers in Louvain, Belgium report.

"Using transgenic mice with diminished levels of the inhibitor of apoptosis protein, survivin, we show that survivin is required to protect the kidney from apoptosis, to suppress renal expression of p53, and to ameliorate renal dysfunction in two models of...

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Source: Gene Therapy Weekly (2008-05-01)

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