Gene Therapy

New findings reported from Harvard University, Medical Department describe advances in gene therapy

Published in Gene Therapy Weekly, May 15th, 2008

"ssDNA-binding proteins are key components of the machinery that mediates replication, recombination, and repair. Prokaryotic ssDNA-binding proteins share a conserved DNA-binding fold and an acidic C-terminal tail," scientists in the United States report.

"It has been proposed that in the absence of ssDNA, the C-terminal tail contacts the ssDNA-binding cleft, therefore predicting that the binding of ssDNA and the C-terminal tail is mutually exclusive. Using chemical cross-linking, competition studies, and NMR chemical-shift mapping, we demonstrate that: (i) the C-terminal peptide of the gene 2.5 protein cross-links to the core of the protein only in the absence of...

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Source: Gene Therapy Weekly (2008-05-15)

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