Life Sciences
Study results from J. Schauber et al provide new insights into life sciences
Published in Gene Therapy Weekly, May 15th, 2008
According to a study from the United States, "Hormonally active vitamin D-3 - 1,25- dihydroxyvitamin D-3 ( 1,25D3) - acts as a signaling molecule in cutaneous immunity by increasing pattern recognition through Toll- like receptor- 2 ( TLR2), and increasing the expression and function of antimicrobial peptides. Here we show that the actions of 1,25D3 on keratinocyte innate immune responses are influenced by histone acetylation and require the steroid receptor coactivator 3 ( SRC3), which mediates inherent histone acetyltransferase ( HAT) activity."
"SRC3 was detected in the suprabasal and granular layer of the skin, similar to cathelicidin expression. HAT activity was...
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Source: Gene Therapy Weekly (2008-05-15)
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