Squamous Cell Carcinoma

Reports outline squamous cell carcinoma research from University of Leipzig

Published in Gene Therapy Weekly, May 15th, 2008

"Pseudoangiosarcomatous squamous cell carcinoma is an unusual but aggressive variant of acantholytic squamous cell carcinoma of the vulva that mimics angiosarcoma on histology. We present a case of a 57-year-old woman with bilateral inguinal metastatic disease at the time of diagnosis, who died 4 months later because of distant metastatic disease to the lungs," scientists in Leipzig, Germany report.

"Molecular analysis did not reveal any human papillomavirus infection. Because of the positive p53 immunostaining and the association to lichen sclerosus and simple type of high-grade vulvar intraepithelial neoplasia, alteration of p53 tumor suppressor gene might be involved...

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Source: Gene Therapy Weekly (2008-05-15)

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