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Cardiomyopathy
Scientists at Charite University discuss research in cardiomyopathy
May 15th, 2008
According to recent research from Berlin, Germany, "The hallmarks of diabetic cardiomyopathy are cardiac oxidative stress, intramyocardial inflammation, cardiac fibrosis, and cardiac apoptosis. Given the antioxidative, antiinflammatory, and antiapoptotic potential of high-density lipoprotein (HDL), we evaluated the hypothesis that increased HDL via gene transfer (GT) with human apolipoprotein (apo) A-I, the principal apolipoprotein of HDL, may reduce the development of diabetic cardiomyopathy." "Intravenous GT with 3 x 10(12) particles/kg of the E1E3E4-deleted vector Ad. hapoA-I, expressing human apoA-I, or Ad. Null, containing no expression cassette, was performed 5 days...
Source: Gene Therapy Weekly (2008-05-15)
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