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Chronic Myeloid Leukemia
Scientists at Shanghai Jiao Tong University publish research in chronic myeloid leukemia
May 15th, 2008
"Acquisition of additional genetic and/or epigenetic abnormalities other than the BCR/ABL fusion gene is believed to cause disease progression in chronic myeloid leukemia (CML) from chronic phase to blast crisis (BC). To gain insights into the underlying mechanisms of progression to BC, we screened DNA samples from CML patients during blast transformation for mutations in a number of transcription factor genes that are critical for myeloid-lymphoid development," researchers in Shanghai, People's Republic of China report. "In 85 cases of CML blast transformation, we identified two new mutations in the coding region of GATA-2, a negative regulator of hematopoietic...
Source: Gene Therapy Weekly (2008-05-15)
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