Enzyme Research
New enzyme research findings from Pennsylvania State University published
Published in Gene Therapy Weekly, May 15th, 2008
"Bacterial EBPs (enhancer-binding proteins) play crucial roles in regulating cellular responses to environmental changes, in part by providing efficient control over all-dependent gene transcription. The AAA+ (ATPase associated with various cellular activities) domain of the EBPs, when assembled into a ring, uses energy from ATP binding, hydrolysis and product release to remodel the sigma(54) -RNAP (RNA polymerase) holoenzyme so that it can transition from closed to open form at promoter DNA," researchers in the United States report.
"The assembly, and hence activity, of these ATPases are regulated by many different signal transduction mechanisms. Recent advances in...
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Source: Gene Therapy Weekly (2008-05-15)
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