Colon Cancer

Findings from Central South University provide new insights into colon cancer

Published in Gene Therapy Weekly, May 15th, 2008

" RNA interference (RNAi) technology is emerging as a very potent tool to generate a cellular knockdown of a desired gene. The aim of this study was to explore whether RNAi targeting vascular endothelial growth factor-C (VEGF-C) could inhibit colorectal tumor lymphangiogenesis and tumor growth," investigators in Changsha, People's Republic of China report.

" We used vector-based RNAi to inhibit VEGF-C expression in colon cancer in vitro and in vivo. VEGF-C expression was quantified by real-time polymerase chain reaction and Westen blotting. To establish LoVo cell tumor xenografts in mice, we subcutaneously inoculated 1.0x10(6) LoVo cells in nude mice; after injection,...

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Source: Gene Therapy Weekly (2008-05-15)

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