Gene Therapy
Data from D. Kamnasaran and colleagues advance knowledge in gene therapy
Published in Gene Therapy Weekly, May 22nd, 2008
According to a study from Toronto, Canada, "Our objective was to determine if murine embryonic stem (ES) cells, which are readily available from repositories, could be developed as a model of gliomagenesis, recognizing the difficulty in obtaining and transforming somatic astrocytes. Using a stringently controlled sequential differentiation procedure on wild type (wt) and p53+/- ES cells, we established GFAP+A2B5-synthetic astrocytes with high efficiency (> 90%)."
"The synthetic astrocytes stably express several differentiated astrocyte associated structural proteins and biochemical markers, but lacked expression of differentiated neurons and oligodendrocytes....
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Source: Gene Therapy Weekly (2008-05-22)
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