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Gene Therapy

Studies from University of Caen describe new findings in gene therapy

Published in Gene Therapy Weekly, May 22nd, 2008

According to recent research from Caen, France, "Type II collagen is composed of alpha 1( II) chains encoded by the COL2A1 gene. Alteration of this cartilage marker is a common feature of osteoarthritis."

"Interleukin-6 (IL-6) is a pro-inflammatory cytokine that needs a soluble form of receptor called sIL-6R to exert its effects in some cellular models. In that case, sIL-6R exerts agonistic action. This mechanism can make up for the partial or total absence of membrane-anchored IL-6 receptors in some cell types, such as chondrocytes. Our study shows that IL-6, sIL-6R, or both inhibit type II collagen production by rabbit articular chondrocytes through a transcriptional...

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