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Cancer Gene Therapy
Data on cancer gene therapy discussed by researchers at Yonsei University
May 29th, 2008
"Anti-tumor-associated glycoprotein ( TAG)-72 PEG-immunoliposomes (PILs) were prepared by conjugation of Fab' fragments of recombinant humanized monoclonal antibody, HuCC49, to sterically stabilize unilamellar liposomes ( 90 - 110 nm in diameter) to target TAG-72-overexpressing cancer cells. The liposomes consisted of 1-palmitonyl-2-oleoyl-sn-glycerol-3-phosphocholine ( POPC), 92 mol percent, O,O'-dymyrisyl-N-lysyl aspartate ( DMKD cationic lipid), 4 mol percent, distearoyl-phosphatidyl-ethanolamine-polyethylene glycol 2000 ( DSPE- PEG(2000)), 3 mol percent and DSPE- maleimide ( DSPE- PEG(2000)-Mal), 1 mol percent," researchers in South Korea report. "These anti-TAG-72...
Source: Gene Therapy Weekly (2008-05-29)
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