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Cancer Gene Therapy
Recent studies from Virginia Commonwealth University, Medical Department add new data to cancer gene therapy
May 29th, 2008
"The prognosis and response to conventional therapies of malignant melanoma inversely correlate with disease progression. With increasing thickness, melanomas acquire metastatic potential and become inherently resistant to radiotherapy and chemotherapy," researchers in the United States report. "These harsh realities mandate the design of improved therapeutic modalities, especially those targeting metastases. To develop an approach to effectively treat this aggressive disease, we constructed a conditionally replication-competent adenovirus in which expression of the adenoviral E1A gene, necessary for replication, is driven by the cancer-specific promoter of...
Source: Gene Therapy Weekly (2008-05-29)
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