Vaccines
Studies from D.E. Speiser et al have provided new data on vaccines
Published in Gene Therapy Weekly, May 29th, 2008
According to a study from Lausanne, Switzerland, "Human cancer vaccines are often prepared with altered ''analog'' or ''heteroclitic'' antigens that have been optimized for HLA class I binding, resulting in enhanced immunogenicity. Here, we take advantage of CpG oligodeoxynucleotides as powerful vaccine adjuvants and demonstrate the induction of high T cell frequencies in melanoma patients, despite the use of natural (unmodified) tumor antigenic peptide."
"Compared with vaccination with analog peptide, natural peptide induced T cell frequencies that were approximately twofold lower. However, T cells showed superior tumor reactivity because of (i) increased functional...
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Source: Gene Therapy Weekly (2008-05-29)
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