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Endotoxemia
Research from T. Peng and co-authors provides new data about endotoxemia
May 29th, 2008
" Lipopolysaccharide (LPS) induces tumor necrosis factor-alpha (TNF-alpha) expression in cardiomyocytes, which contributes to myocardial dysfunction during sepsis. The purpose of this study was to investigate the role of phosphatidylinositol (PI) phospholipase C gamma 1 (PLC gamma 1) in cardiac TNF-alpha expression, and myocardial dysfunction during endotoxemia," investigators in London, Canada report. "Methods and results In cultured mouse neonatal cardiomyocytes, LPS increased PLC gamma 1 phosphorylation. Knockdown of PLC gamma 1 with specific siRNA or inhibition of PLC gamma 1 with U73122 attenuated TNF-alpha expression induced by LPS. This action of PLC gamma 1 was...
Source: Gene Therapy Weekly (2008-05-29)
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