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Enzyme Research
New enzyme research study findings reported from Johns Hopkins University
May 29th, 2008
"The active site of thioredoxin-1 (Trx1) is oxidized in cells with increased reactive oxygen species (ROS) and is reduced by thioredoxin reductase-1 (TrxR 1). The purpose of the present study was to determine the extent to which the redox state of Trx 1 is sensitive to changes in these opposing reactions," investigators in the United States report. "Trx1 redox state and ROS generation were measured in cells exposed to the TrxR1 inhibitors aurothioglucose (ATG) and monomethylarsonous acid (MMA(III)) and in cells depleted of TrxR1 activity by siRNA knock down. The results showed that all three treatments inhibited TrxR1 activity to similar extents (90% inhibition), but...
Source: Gene Therapy Weekly (2008-05-29)
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