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Gene Therapy
New gene therapy research has been reported by scientists at University College
May 29th, 2008
According to recent research published in the journal Molecular Therapy, "Gene therapy for X-linked severe combined immunodeficiency (SCID-X1) has proven highly effective for long- term restoration of immunity in human subjects. However, the development of lymphoproliferative complications due to dysregulated proto-oncogene expression has underlined the necessity for developing safer vector systems."
"To reduce the potential for insertional mutagenesis, we have evaluated the efficacy of self-inactivating (SIN) gammaretroviral vectors in cellular and in vivo models of SCID-X1. Vectors incorporating an internal human elongation factor-1a regulatory element...
Source: Gene Therapy Weekly (2008-05-29)
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