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Bioengineering
Recent findings from Osaka University, Medical Department highlight research in bioengineering
May 29th, 2008
"The success of pancreatic islet transplantation is limited because of the severe shortage of allogeneic pancreas donors. Accordingly, pig islets are considered to be an attractive, promising alternative," scientists writing in the journal Transplantation Proceedings report. "However, cell-mediated immunity, especially CD8(+) cytotoxic T lymphocyte (CTL)-mediated cytotoxicity, remains a formidable barrier to prevent long-term islet survival in xenograft recipients. Therefore, it is particularly important to explore methods to specifically prevent cell-mediated immunity against pig islets. Our group previously demonstrated that the overexpression of either...
Source: Gene Therapy Weekly (2008-05-29)
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