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Gene Therapy
Research findings from University of Hyogo update understanding of gene therapy
May 29th, 2008
"Perilipin is a protein localized on lipid droplet surfaces in adipocytes and steroidogenic cells, playing a central role in regulated lipolysis. Expression of the perilipin gene is markedly induced during adipogenesis," investigators in Kamigori, Japan report. "We found that transcription from the perilipin gene promoter is activated by an orphan nuclear receptor, estrogen receptor-related receptor (ERR)a. A response element to this receptor was identified in the promoter region by a gene reporter assay, the electrophoretic-gel mobility-shift assay and the chromatin immunoprecipitation assay. Peroxisome proliferator-activated receptor 7 coactivator (PGC)- I alpha...
Source: Gene Therapy Weekly (2008-05-29)
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