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Gene Therapy
Researchers from St. Vincent's Hospital report on findings in gene therapy
May 29th, 2008
"RNA interference is a conserved process by which sequence-specific double-stranded RNA is converted into small interfering double-stranded RNAs (siRNAs) that can induce gene silencing via two pathways: post-transcriptional gene silencing and transcriptional gene silencing (TGS). We previously reported TGS of human immunodeficiency virus- 1 (HIV-1) could be induced by siRNAs targeting regions within its 5'-long-terminal repeat (5' LTR) promoter region," scientists in Sydney, Australia report. "Here we show that promoter-targeted siRNAs can also induce silencing of simian immunodeficiency virus (SIV) replication by similar mechanisms. Suppression of productive infection...
Source: Gene Therapy Weekly (2008-05-29)
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