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Gene Therapy
Researchers from University of Manitoba detail findings in gene therapy
May 29th, 2008
"DIx homeobox genes are first expressed in embryonic retina at E11.5. The DIx1/DIx2 null retina has a reduced ganglion cell layer (GCL), with loss of late-born differentiated retinal ganglion cells (RGCs) due to increased apoptosis," scientists in Winnipeg, Canada report. "TrkB signaling is proposed to regulate the dynamics of RGC apoptosis throughout development. DLX2 expression markedly precedes the onset of TrkB expression in the GCL; TrkB co-expression with DIx2 and RGC markers is well-established by E13.5. In the DIx1/DIx2 null retina, TrkB expression is significantly reduced by E16.5. We demonstrated that DLX2 binds to a specific region of the TrkB promoter in...
Source: Gene Therapy Weekly (2008-05-29)
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