Antisense Technology

Research from University of Geneva, Medical Department provides new data on antisense technology

Published in Gene Therapy Weekly, June 5th, 2008

"The elucidation of the largely unknown transcriptome of small RNAs is crucial for the understanding of genome and cellular function. We report here the results of the analysis of small RNAs (< 50 nt) in the ENCODE regions of the human genome," scientists writing in the American Journal of Human Genetics report.

"Size-fractionated RNAs from four different cell lines (HepG2, HelaS3, GM06990, SK-N-SH) were mapped with the forward and reverse ENCODE high-density resolution tiling arrays. The top 1% of hybridization signals are termed SmRfrags (Small RNA fragments). Eight percent of SmRfrags overlap the GENCODE genes (CDS), given that the majority map to...

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Source: Gene Therapy Weekly (2008-06-05)

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