Gene Therapy

Researchers from University of Toulouse describe findings in gene therapy

Published in Gene Therapy Weekly, June 5th, 2008

According to recent research published in the journal Technology in Cancer Research & Treatment, "RNA interference appears as a promising tool for therapeutic gene silencing. A key limit is the delivery of the siRNA."

"A safe approach is to use a physical method such as in vivo electropulsation with contact electrodes. Getting a long lived silencing can be better approached by using the in situ expression of shRNA. This is presently obtained by using co-electrotransfer of specific plasmids coding for expression and silencing of a fluorescent protein. Using a non invasive fluorescence imaging assay, electrodelivery in mouse muscles is observed to induce complete...

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Source: Gene Therapy Weekly (2008-06-05)

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