Allergies

New allergies research from V. Casolaro et al outlined

Published in Gene Therapy Weekly, June 5th, 2008

"IL-13, a critical cytokine in allergy, is regulated by as-yet-elusive mechanisms. We investigated IL-13 posttranscriptional regulation by HuR, a protein associating with adenylate-uridylate-rich elements in the 3' untranslated regions (UTRs) of mRNA, promoting mRNA stability and translation," scientists writing in the Journal of Allergy and Clinical Immunology report.

"IL-13 mRNA decay was monitored in human T(H)2-skewed cells by using the transcriptional inhibitor actinomycin D. The IL-13 3'UTR was subcloned into an inducible beta-globin reporter transiently expressed in H2 cells in the absence or presence of overexpressed HuR. Association of HuR with IL-13...

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Source: Gene Therapy Weekly (2008-06-05)

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