Gastric Cancer Genetics
Royal Melbourne Hospital details research in gastric cancer genetics
Published in Gene Therapy Weekly, June 12th, 2008
A report, 'STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice,' is newly published data in The Journal of Clinical Investigation. "Deregulated activation of STAT3 is frequently associated with many human hematological and epithelial malignancies, including gastric cancer. While exaggerated STAT3 signaling facilitates an antiapoptotic, proangiogenic, and proproliferative environment for neoplastic cells, the molecular mechanisms leading to STAT3 hyperactivation remain poorly understood," researchers in Melbourne, Australia report.
"Using the gp130(Y757F/Y757F) mouse model of gastric cancer, which...
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Source: Gene Therapy Weekly (2008-06-12)
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