Journal of the National Cancer Institute
Also in the May 27 JNCI
Published in Gene Therapy Weekly, June 12th, 2008
Mutations in the p14ARF tumor suppressor gene (ARF) may play a role in melanoma, independent of the effect of the p16 gene.
ARF and p16 are overlapping genes at a location on chromosome 9 that is frequently mutated in melanomas. Although researchers have previously demonstrated that inactivation of the p16 tumor suppressor gene occurs frequently in melanomas, it has been less clear whether alterations in ARF occur independently of p16 in human melanoma.
In the current study, David Polsky, M.D., Ph.D., of the New York University School of Medicine and colleagues...
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Source: Gene Therapy Weekly (2008-06-12)
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