Gene Therapy
Research conducted at D. Zychlinski and co-authors has provided new information about gene therapy
Published in Gene Therapy Weekly, June 12th, 2008
"The possible activation of cellular proto-oncogenes as a result of clonal transformation is a potential limitation in a therapeutic approach involving random integration of gene vectors. Given that enhancer promiscuity represents an important mechanism of insertional transformation, we assessed the enhancer activities of various cellular and retroviral promoters in transient transfection assays, and also in a novel experimental system designed to measure the activation of a minigene cassette contained in stably integrating retroviral vectors," researchers in Hannover, Germany report.
"Retroviral enhancer-promoters showed a significantly greater potential to activate...
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Source: Gene Therapy Weekly (2008-06-12)
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