Cancer Gene Therapy

New cancer gene therapy data have been reported by researchers at Stanford University, Medical Department

Published in Gene Therapy Weekly, June 19th, 2008

According to a study from the United States, "Clinical use of cancer gene therapy has been prevented by the inability to deliver high levels of local transgene expression with acceptable host toxicity. The authors' laboratory has developed an ex vivo technique to genetically modify free flaps to deliver immunotherapy locally without systemic toxicity."

"Superficial inferior epigastric flaps were dissected in Fischer rats, perfused with a viral vector expressing the antitumor interleukin-12 (IL-12) for 1 hour, and re-anastomosed. Beneath the flaps was a bolus of 1 x 10(6) beta-human chorionic gonactotropin-sccreting MADB-106 tumor cells. Tumor growth was monitored using...

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Source: Gene Therapy Weekly (2008-06-19)

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