Hepatitis B Virus
New hepatitis B virus research from University of Bern, Department of Clinical Research outlined
Published in Gene Therapy Weekly, June 19th, 2008
Investigators publish new data in the report 'Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus.' "APOBEC3 editing enzymes inhibit retroviruses by cytidine deamination in minus-strand cDNA, leading to G to A hypermutated proviruses, and by less well characterized inhibition of retroviral replication independently of catalysis. This review focuses on the effects of APOBEC3 enzymes on the pararetrovirus hepatitis B virus," scientists in Berne, Switzerland report.
"The cytidine deaminases APOBEC3B, APOBEC3C, APOBEC3F and APOBEC3G deaminate cytidine residues in hepatitis-B-virus...
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Source: Gene Therapy Weekly (2008-06-19)
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