Alzheimer Disease

Studies in the area of Alzheimer disease reported from Medical University of South Carolina

Published in Gene Therapy Weekly, June 19th, 2008

"it is well established that the extracellular deposition of amyloid beta (A beta) peptide plays a central role in the development of Alzheimer's disease (AD). Therefore, either preventing the accumulation of A beta peptide in the brain or accelerating its clearance may slow the rate of AD onset," scientists writing in the American Journal of Pathology report.

"Neprilysin (NEP) is the dominant A beta peptide-degrading enzyme in the brain; NEP becomes inactivated and down-regulated during both the early stages of AD and aging. in this study, we investigated the effect of human (h)NEP gene transfer to the brain in a mouse model of AD before the development of...

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Source: Gene Therapy Weekly (2008-06-19)

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