Angiogenesis

Researchers at Osaka University publish new data on angiogenesis

Published in Gene Therapy Weekly, June 19th, 2008

"Dual-targeted therapy for antiangiogenesis and antilymphangiogenesis represents a potentially effective strategy for the treatment of various malignancies. Therefore, the goal of the present study was to identify genes that encode inhibitors of both angiogenesis and lymphangiogenesis," scientists in Suita, Japan report.

"Using a cDNA library obtained from Lewis lung carcinoma (LL/2), a candidate gene was identified by the evaluation of growth inhibition in aortic and lymphatic endothelial cells (EC) as that coding for the mouse cold shock domain protein A (mCSDA). Overexpression of mCSDA significantly repressed cell proliferation and c-fos promoter activity in aortic,...

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Source: Gene Therapy Weekly (2008-06-19)

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