Fetal Growth Retardation Gene Therapy
Investigators at University of California, Research Center have published new data on fetal growth retardation gene therapy
Published in Gene Therapy Weekly, June 26th, 2008
New investigation results, 'Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspring,' are detailed in a study published in Journal of Biological Chemistry. "We examined transcriptional and epigenetic mechanism(s) behind diminished skeletal muscle GLUT4 mRNA in intrauterine growth-restricted (IUGR) female rat offspring. An increase in MEF2D (inhibitor) with a decline in MEF2A (activator) and MyoD (co-activator) binding to the glut4 promoter in IUGR versus control was observed," investigators in the United States report.
"The functional role of MEF2/MyoD-binding sites and neighboring three CpG clusters in...
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Source: Gene Therapy Weekly (2008-06-26)
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