Gene Therapy

Study results from University of Texas update understanding of gene therapy

Published in Gene Therapy Weekly, June 26th, 2008

According to recent research from the United States, "Radioresistance may be caused by cancer stem cells (CSC). Because CSCs require telomerase to proliferate, a telomerase-specific oncolytic adenoviral vector carrying apoptotic tumor necrosis factor -related apoptosis-inducing ligand and E1A gene (Ad/TRAIL-E1) may preferentially target CSCs."

"We established two pairs of parental and radioresistant (R) esophageal carcinoma cell lines (Seg-1, Seg-1R and TE-2,TE-2R) by fractionated irradiation. Stem cell markers were measured by Western blotting and flow cytometry. Serial sorting was used to enrich stem-like side population cells. Telomerase activity, transgene...

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Source: Gene Therapy Weekly (2008-06-26)

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