Breast Cancer

Researchers at University of Texas release new data on breast cancer

Published in Gene Therapy Weekly, July 3rd, 2008

According to recent research published in the Journal of Cellular Biochemistry, "Cofactor of BRCA1 (COBRA1) is an integral component of the human negative elongation factor (NELF), a four-subunit protein complex that inhibits transcription elongation. Previous in vivo work indicates that COBRA1 and the rest of the NELF complex repress estrogen-dependent transcription and the growth of breast cancer cells."

"In light of the COBRA1 function in breast cancer-related gene expression, we sought to examine regulation of COBRA] expression in both established breast cancer cell lines and breast carcinoma tissues. We found that COBRA1 expression was inversely correlated...

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Source: Gene Therapy Weekly (2008-07-03)

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