Gene Therapy

Reports outline gene therapy research from Albanova University

Published in Gene Therapy Weekly, July 3rd, 2008

"The epidermal growth factor receptor 1 (EGFR) is overexpressed in various malignancies and is associated with a poor patient prognosis. A small, receptor-specific, high-affinity imaging agent would be a useful tool in diagnosing malignant tumors and in deciding upon treatment and assessing the response to treatment," researchers in Stockholm, Sweden report.

"We describe here the affinity maturation procedure for the generation of Affibody molecules binding with high affinity and specificity to EGFR. A library for affinity maturation was constructed by rerandomization of selected positions after the alignment of first-generation binding variants. New binders were...

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Source: Gene Therapy Weekly (2008-07-03)

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