Bladder Cancer

Findings from P. Mhawechfauceglia and co-authors provide new insights into bladder cancer

Published in Gene Therapy Weekly, July 3rd, 2008

"TSC1/hamartin is a tumor suppressor gene involved in the development of various malignancies, including bladder cancer. In vitro studies showed that hamartin controls cell proliferation partly by up-regulating p27 and 14-3-3 sigma," scientists writing in the American Journal of Clinical Pathology report.

"This study was designed to explore the value of these biomarkers in predicting outcome in pTa/pT1 tumors and validate the regulation of p27 and 14-3-3 sigma by hamartin in vivo using human bladder cancer tissue. A tissue microarray of 134 pTa and pT1 tumors was constructed, and sections were stained with hamartin, 14-3-3 sigma, and p27 antibodies. In multiple...

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Source: Gene Therapy Weekly (2008-07-03)

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