HIV/AIDS

Studies from University of California add new findings in the area of HIV/AIDS

Published in Gene Therapy Weekly, July 3rd, 2008

According to recent research from the United States, "Efficient inhibition of the HIV infection, life cycle at the stages of viral infection, reverse transcription, and post-translational processing has been extensively studied. However, efficient inhibition of HIV assembly and budding has not been reported."

"Here, we report that dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) -grabbing nonintegrin (DC-SIGN) and its related protein, DC-SIGNR, effectively block HIV budding from infected cells. Cotransfection of DC-SIGN or DC-SIGNR with HIV demonstrated 95-99.5% inhibition of viral production from host cells. DC-SIGN or DC-SIGNR can also effectively...

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Source: Gene Therapy Weekly (2008-07-03)

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