Apoptosis

Data on apoptosis reported by researchers at University of Oxford

Published in Gene Therapy Weekly, July 10th, 2008

"Osteoblasts undergo apoptosis both in vitro and in vivo in response to high dose glucocorticoid (GC) treatment. However, the molecular mechanisms remain elusive, hindering the prevention and treatment of this side-effect," investigators in Oxford, the United Kingdom report.

"Apoptosis was induced by dexamethasone (Dex) in murine MBA-15.4 osteoblasts within 24-48 h of treatment. We found dose- and time-dependent upregulation of Bim protein, a pro-apoptotic Bcl-2 family member, with highest levels at 24-48 h for 1 mc M Dex. This was also observed in primary human bone marrow stromal cells. Bim is subjected to stringent transcriptional and post-translational regulation in...

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Source: Gene Therapy Weekly (2008-07-10)

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