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Diabetic Retinopathy
New research on diabetic retinopathy from Nagoya City University summarized
July 17th, 2008
According to recent research published in the journal Graefes Archive for Clinical and Experimental Ophthalmology, " The pathology of diabetic retinopathy involves endothelial dysfunction, in which leukocyte adhesion to the vascular endothelium via intercellular adhesion molecule-1 (ICAM-1) may play a key role. Short-interfering RNAs (siRNAs) are unique modulators of gene expression in mammalian cells." "The purpose of this study was to evaluate the enhanced effect of hyperglycemia and the attenuating effect of siRNAs on ICAM-1 expression in cultured endothelial cells. Human umbilical vein endothelial cells (HUVECs) were seeded onto 24-well culture plates. The...
Source: Gene Therapy Weekly (2008-07-17)
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