Gene Therapy Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
DNA Vaccines
Reports outline DNA vaccines study results from Johns Hopkins University, Medical Department
July 17th, 2008
"CD4(+) T helper cells are known to play an integral role in the generation of CD8(+) T-cell immune responses. We have previously shown that co-administration of DNA vaccines containing E6 or E7 protein of human papillomavirus 16 (HPV-16) combined with DNA encoding invariant (li) chain in which class II- associated Ii peptide ( CLIP) region is replaced with the CD4+ T helper epitope, PADRE (Pan-DR-epitope) (Ii-PADRE DNA) enhanced HPV antigen-specific CD8(+) T-cell immune responses in vaccinated mice," scientists in the United States report. "In the current study, we investigated the enhancement of HPV E7- specific CD8(+) T-cell immune responses by PADRE- specific CD4+ T...
Source: Gene Therapy Weekly (2008-07-17)
|
