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Epstein-Barr Virus
Studies by A. Wiedmer and co-authors describe new findings in Epstein-Barr virus
July 17th, 2008
"Disruption of cellular metabolic processes and usurpation of host proteins are hallmarks of herpesvirus lytic infection. Epstein-Barr virus (EBV) lytic replication is initiated by the immediate-early protein Zta," scientists in the United States report. "Zta is a multifunctional DNA binding protein that stimulates viral gene transcription, nucleates a replication complex at the viral origin of lytic replication, and inhibits cell cycle proliferation. To better understand these functions and identify cellular collaborators of Zta, we purified an epitope-tagged version of Zta in cells capable of supporting lytic replication. FLAG-tagged Zta was purified from a nuclear...
Source: Gene Therapy Weekly (2008-07-17)
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