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Whitehead Institute for Biomedical Research

New technique produces genetically identical stem cells

Published in Gene Therapy Weekly, July 17th, 2008

CAMBRIDGE, Mass. (July 1, 2008) – Adult cells of mice created from genetically reprogrammed cells—so-called induced pluripotent stem (IPS) stem cells—can be triggered via drug to enter an embryonic-stem-cell-like state, without the need for further genetic alteration.

The discovery, which promises to bring new efficiencies to embryonic stem cell research, is reported in the July 1, 2008, online issue of Nature Biotechnology.

"This technical advancement will allow thousands of identical reprogrammed cells to be used in experiments," says Marius Wernig, one of the paper's two lead authors and a postdoctoral researcher in Whitehead Member Rudolf...

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