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Gene Therapy
Data from N. Kotobuki and colleagues advance knowledge in gene therapy
July 17th, 2008
According to recent research published in the journal Cell and Tissue Research, "To investigate the cascade of matrix mineralization, cells expressing high and low alkaline phosphatase (ALP) were separated from human osteoblast-like (HOS) cells by fluorescence-activated cell sorting with an ALP antibody. After these cells had been recloned from single cells and then cultured under osteogenic conditions, high-ALP-expressing HOS (H-HOS) cells showed matrix mineralization, but low-ALP-expressing HOS (L-HOS) cells did not." "The interaction among osteogenic-related genes, such as runt-related transcription factor 2 (RUNX2), collagen type I alpha 1 chain (COL1A1),...
Source: Gene Therapy Weekly (2008-07-17)
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