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Adenovirus
New adenovirus research has been reported by scientists at University of Oxford
July 17th, 2008
According to recent research from Oxford, the United Kingdom, "Direct intratumoural ( IT) administration of adenovirus is widely used, however little is known about the resulting distribution of virus particles. Here we have evaluated the influence of tumour size, volume of injectate and occlusion of injection sites ( to prevent retrograde seepage) on particle biodistribution and transgene expression." "In subcutaneous MDA-231 xenografts, IT injection of relatively large volumes ( 4 x 20% ( vol/ vol) injections) resulted in just 40% of the administered dose being retained in tumour tissue after 30 min, with 15% in the liver thought to reflect systemic 'overflow'....
Source: Gene Therapy Weekly (2008-07-17)
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