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Gene Therapy
Report summarizes gene therapy study findings from University of Kuopio
July 17th, 2008
"Longitudinal and transverse relaxations in the rotating frame, with characteristic time constants T-1 rho and T-2 rho, respectively, have potential to provide unique MRI contrast in vivo. On-resonance spin-lock T-1 rho with different spin-lock field strengths and adiabatic T-2 rho with different radiofrequency-modulation functions were measured in BT4C gliomas treated with Herpes Simplex Virus thymidine kinase (HVS-tk) gene therapy causing apoptotic cell death," investigators in Kuopio, Finland report. "These NMR tools were able to discriminate different treatment responses in tumor tissue from day 4 onward. An equilibrium two-site exchange model was used to calculate...
Source: Gene Therapy Weekly (2008-07-17)
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