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Gene Therapy
Reports from Y. Zeng and colleagues advance knowledge in gene therapy
July 17th, 2008
" Delivery of transgenes into specific tissues by adenovirus vectors (AdVs) relies on ablations of their natural tropism and on introduction of a new tropism. If the interaction with its natural receptor is ablated, a new packaging cell line is required to produce the AdV," scientists writing in the Journal of Gene Medicine report. "In the present study, we have used two de novo designed peptides (E-Coil and K-Coil) that interact with each other with high affinity to establish a new receptor-ligand system for the propagation of retargeted AdVs. We produced a cell line (293E) expressing on its surface a pseudoreceptor containing the E-Coil. An AdV (AdFK4m/GFP)...
Source: Gene Therapy Weekly (2008-07-17)
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