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Gene Therapy
Reports on gene therapy findings from Southern Illinois University, Medical Department provide new insights
July 17th, 2008
According to recent research from the United States, "MicroRNAs (miR-NAs) are a class of naturally occurring small non-coding RNAs that target protein-coding mRNAs at the post-transcriptional level. Our previous studies suggest that mir-21 functions as an oncogene and has a role in tumorigenesis, in part through regulation of the tumor suppressor gene tropomyosin 1 (TPM1)." "Given that TPM1 has been implicated in cell migration, in this study we further investigated the role of mir-21 in cell invasion and tumor metastasis. We found that suppression of mir-21 in metastatic breast cancer MDA-MB-231 cells significantly reduced invasion and lung metastasis. Consistent with...
Source: Gene Therapy Weekly (2008-07-17)
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